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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERN1
All Species:
23.94
Human Site:
S399
Identified Species:
40.51
UniProt:
O75460
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75460
NP_001424.3
977
109735
S399
P
A
D
S
E
K
K
S
F
E
E
V
I
N
L
Chimpanzee
Pan troglodytes
XP_511585
968
108684
S407
Y
S
E
S
S
G
T
S
S
P
S
T
S
P
R
Rhesus Macaque
Macaca mulatta
XP_001109583
1070
119711
S492
P
A
D
S
E
K
K
S
F
E
E
V
I
N
L
Dog
Lupus familis
XP_853409
975
109686
S399
P
A
D
S
E
K
K
S
F
E
E
V
I
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQY0
977
110166
S401
P
A
D
S
E
K
R
S
F
E
E
V
I
N
I
Rat
Rattus norvegicus
XP_573211
965
109012
S389
P
A
D
S
E
K
R
S
F
E
E
V
I
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510886
942
106736
P387
E
D
L
P
P
T
T
P
Q
D
I
E
E
T
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085649
958
108223
L398
R
G
S
T
P
R
T
L
F
D
D
F
L
T
P
Zebra Danio
Brachydanio rerio
XP_001919350
921
102695
P386
R
S
G
D
V
I
P
P
R
G
S
G
S
S
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097839
1074
120152
S392
Q
L
S
P
T
T
A
S
S
K
V
V
Q
S
L
Honey Bee
Apis mellifera
XP_392044
968
110555
S387
P
L
Q
I
T
G
R
S
D
P
V
I
E
T
L
Nematode Worm
Caenorhab. elegans
Q09499
967
109804
K400
Y
P
V
P
G
P
H
K
A
I
G
S
T
I
E
Sea Urchin
Strong. purpuratus
XP_786178
1112
123199
P413
H
L
S
K
P
S
E
P
R
P
F
P
E
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32361
1115
126957
T469
K
T
N
S
L
D
T
T
H
K
Y
P
P
L
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.7
90.3
95.5
N.A.
93.1
92.1
N.A.
83
N.A.
56
57
N.A.
37.7
43
41.3
41.4
Protein Similarity:
100
84.8
91
97.3
N.A.
96.3
94.8
N.A.
89.3
N.A.
71.4
69.8
N.A.
52.9
58.6
59.3
54.4
P-Site Identity:
100
13.3
100
100
N.A.
86.6
93.3
N.A.
6.6
N.A.
6.6
0
N.A.
20
20
0
0
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
13.3
N.A.
40
13.3
N.A.
33.3
33.3
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
36
0
0
0
0
8
0
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
36
8
0
8
0
0
8
15
8
0
0
0
0
% D
% Glu:
8
0
8
0
36
0
8
0
0
36
36
8
22
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
43
0
8
8
0
0
0
% F
% Gly:
0
8
8
0
8
15
0
0
0
8
8
8
0
0
0
% G
% His:
8
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
0
0
0
8
8
8
36
8
8
% I
% Lys:
8
0
0
8
0
36
22
8
0
15
0
0
0
8
0
% K
% Leu:
0
22
8
0
8
0
0
8
0
0
0
0
8
8
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
0
36
0
% N
% Pro:
43
8
0
22
22
8
8
22
0
22
0
15
8
8
8
% P
% Gln:
8
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
15
0
0
0
0
8
22
0
15
0
0
0
0
0
8
% R
% Ser:
0
15
22
50
8
8
0
58
15
0
15
8
15
15
0
% S
% Thr:
0
8
0
8
15
15
29
8
0
0
0
8
8
22
0
% T
% Val:
0
0
8
0
8
0
0
0
0
0
15
43
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _